争霸8官方入口

争霸8官方入口:争霸8官方入口

College of Biological Science and Engineering

黄祖雄*

发布日期:2013-06-27 发布者:

姓名:黄祖雄

性别:

职务:主任医师/硕士生导师

学历:博士

电子邮件: 2556356068@qq.com

主要研究方向:肝病与宿主免疫

教育工作经历:

1996/9-2001/7:  福建医科大学,临床医学,学士

2001/9-2004/7:  福建医科大学,儿科学,硕士

2004/9-2009/12:福州市传染病院,感染科,住院医师

2009/12-2016/12: 福建医科大学孟超肝胆医院,肝病内科,主治医师

2011/9-2014/7: 南方医科大学,感染病学,博士

                                   2016/12-至今,福建医科大学孟超肝胆医院,肝病内科,副主任医师

                                   2021/9至今,争霸8官方入口孟超医学与交叉科学中心,硕士生导师

教学简介:


科研简介:以临床队列为基础,利用分子生物学、生物化学、细胞生物学、免疫学等技术从事肝病与宿主免疫相关的机制研究。已在Aliment Pharmacol Ther、Hepatology international、Frontiers in Immunology、Antiverial Research等国际刊物发表SCI论文十余篇。主持国家自然科学基金项目1项,省部级项目3项,多项国家级横向项目及厅局级项目。

社会兼职:中华医学会肝病学分会青年委员,中华医学会感染病学分会青年委员,中国医师协会感染科医师分会青年委员,福建省医学会感染病学分会常务委员,福建省医学会肝病学分会委员。Infectious diseases & immunity、Journal of Gastroenterology and Hepatology》 审稿人,《福建医科大学学报》青年编委、《临床肝胆病杂志》青年编委。

科研项目:

1. Toll样受体信号通路及miR-155在慢性乙型肝炎患者自然杀伤细胞功能失衡中的作用及机制研究,国家自然科学基金面上项目,2016/01-2020/12,编号:81670532,58万,主持。

2. 肠道菌群介导LPS/AMPK通路在浒苔多糖改善NAFLD肝纤维化的作用及调控机制,福建省卫生健康中青年骨干人才培养项目,2022/10-2025/10,编号:2022GGA050,10万,主持。

3. 中性粒细胞胞外诱捕网在慢加急性肝衰竭中的作用,福建自然科学基金面上项,2020/11-2023/11,编号: 2020J01121332,8万,主持。

4. 靶向Toll样受体8信号通路调控慢性乙型肝炎患者自然杀伤细胞功能的研究,福州市卫生健康科技计划项目,2020/10-2023/10,编号: 2020-S-wt4,16万,主持。

5. 血小板ADP抑制率作为乙肝相关终末期肝病分层诊断新型标记物的验证性研究,艾滋病和病毒性肝炎等重大传染病防治科技重大专项,2019/01-2021/12,编号:2018ZX10723203-004,57万,子任务负责人

6. Toll样受体信号通路及其下游miR-155参与慢性乙型肝炎患者自然杀伤细胞功能调控的作用及机制,福建自然科学基金面上项目,2015/09-2019/09,编号:2015J01361,8万,主持。

已发表论文:

1. Ao Xiulan., Gan Qiaorong., Huang Xuan., Bao Dongpeng., Wu Xuwei., Lin Qiuxiang., Lin Aifang., Ding Yating., Wang Lingxia., Chen Yanping., Huang Zuxiong*.TLR8 agonist partially improves IFN-γ deficiency of NK cells in chronic hepatitis B through the synergy of monocytes. Aliment Pharmacol Ther, 2023, 57(4), 387-398. doi:10.1111/apt.17382

2. Huang Z, Wang N, Huang S, Chen Y, Yang S, Gan Q, Ye H, Liu B, Pan C. Increased Serum Soluble Urokinase Plasminogen Activator Receptor Predicts Short-Term Outcome in Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure. Gastroenterol Res Pract, 2019(undefined), 3467690. doi:10.1155/2019/3467690

3. Huang Z, Ge J, Pang J, Liu H, Chen J, Liao B, Huang X, Zuo D, Sun J, Lu M, Zhang X, Hou J.Aberrant expression and dysfunction of TLR2 and its soluble form inchronic HBV infection and its regulation by antiviral therapy. Antiviral Research.2015,118(2015):10-19

4. Huang Z, Lin C, Fang J, Wang N, Zhou R, Pan C.Acute kidney injury in hepatitis B-related acute-on-chronic liver failure without preexisting liver cirrhosis. Hepatol Int.2015,9(3):416-423

5. Ge J#, Huang Z#, Liu H, Chen J, Xie Z, Chen Z, Peng J, Sun J, Hou J, Zhang X. Lower Expression of MicroRNA-155 Contributes to Dysfunction of Natural Killer Cells in Patients with Chronic Hepatitis B. Front Immunol. 2017 Sep 22;8:1173. doi: 10.3389/fimmu.2017.01173. (#共同一作)

6. Chen Y#, Huang Z#, Ma D, Chen L, Lai Q, Huang X, Zhou J, Zhang X, Ma Q, Chen Z, Zuo D. Involvement of soluble scavenger receptor A in suppression of T cell activation in patients with chronic hepatitis B.BMC Immunol. 2015,1629(#共同一作)

7. Lai Q, Ma S, Ge J, Huang Z, Huang X, Jiang X, Li Y, Zhang M, Zhang X, Sun J,Abbott WG, Hou J. TCRγδ(+)CD4(-)CD8(-) T cells suppress the CD8(+) T-cell response to hepatitis B virus peptides, and are associated with viral control in  chronic hepatitis B. PLoS One. 2014,14;9(2):e88475.

8. Chen L, Zheng CX, Lin MH, Huang ZX, Chen RH, Li QG, Li Q, Chen P. Distinct quasispecies characteristics and positive selection within precore/core gene in hepatitis B virus HBV associated acute-on-chronic liver failure. J Gastroenterol Hepatol. 2013,28(6):1040-6.

9. Liao B, Wang Z, Lin S, Xu Y, Yi J, Xu M, Huang Z, Zhou Y, Zhang F, Hou J.Significant fibrosis is not rare in Chinese chronic hepatitis B patients with persistent normal ALT. PLoS One. 2013,8(10):e78672.

10. Zhou R, Pan F, Lin C, Lin X, Gao H, Huang S, Huang Z, Lin Y, Pan C, Zhou Y. Baseline prognostic factors and statistic model to predict early virological response in lamivudine-treated patients with chronic hepatitis B. Int J Clin Exp Med. 2015,8(10):19258-65.

11. Deng G, Ge J, Liu C, Pang J, Huang Z, Peng J, Sun J, Hou J, Zhang X. Impaired expression and function of TLR8 in chronic HBV infection and its association with treatment responses during peg-IFN-α-2a antiviral therapy. Clin Res Hepatol Gastroenterol. 2017,S2210-7401(17)30005-0.

12. Lai J, Liu Y, Pan C, Lin C, Sun F, Huang Z, Lin Y, Zhou R, Lin Y, Zhou Y. Interleukin-1 receptor antagonist expression is inversely associated with outcomes of hepatitis B-related acute-on-chronic liver failure. Exp Ther Med.2017,13(6):2867-2875.



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