争霸8官方入口

争霸8官方入口:争霸8官方入口

College of Biological Science and Engineering

张晓龙*

发布日期:2013-06-27 发布者:

姓名:张晓龙

性别:

职称:副研究员/硕士生导师

学历:博士

电子邮件: xiaolongdo@gmail.com

主要研究方向:纳米生物医学,肿瘤分子影像,纳米生物传感

教育工作经历:

1.2005/9–2009/7,争霸8官方入口,化学,学士

2.2009/9–2015/7,争霸8官方入口,分析化学,博士

3.2015/7 至今,福建医科大学孟超肝胆医院,助理研究员,副研究员

4.2018/1 至今,争霸8官方入口孟超医学与交叉科学中心,副研究员

教学简介:


科研简介:主要从事肿瘤诊断分子影像探针和纳米药物的开发及应用,实现肿瘤的光学成像、光动力、光热或化学治疗等基础研究工作。已在Acta Biomaterialia、Molecular Therarpy、Anal. Chem.、Chem. Commun.、ACS Appl. Mater. Interfaces、Theranostics、Biosens. Bioelectron.、 Nanoscale、 Sensors & Actuators: B. Chemical、Microchimica Acta、Talanta、Analytical and Bioanalytical Chemistry等等国际刊物发表SCI论文20余篇。主持国家自然科学基金项目1项,省部级项目3项。2021年入选福建省高层次人才(C类)。

社会兼职:Theranostics》、《Acta Biomaterialia》、《Materials Today Bio》、《Materials & Design》、《Frontiers in Chemistry》、《Talanta》、《Arabian Journal of Chemistry》、《Analytical Biochemistry》、《International Journal of Nanomedicine等杂志审稿人。

科研项目:

1. 福建省自然科学基金面上项目,2021J011281,仿生纳米材料协同化学动力和光动力治疗乏氧肿瘤,2021/11-2024/11,7万元,在研,主持

2. 福建省卫健委医学创新课题,2021CXA043,光敏剂和核酸共递送纳米体系用于乏氧肿瘤的基因-光动力治疗协同增效研究,2022/1-2024/12,15万元,在研,主持

3. 国家自然科学基金青年项目,21605021,核酸功能化聚吡咯纳米体系在肿瘤细胞靶向成像与治疗中的研究,2017/01-2019/12,20万,结题,主持

4. 福建省自然科学基金-青年科技人才创新项目,2016J05206,核酸功能化荧光纳米探针在细胞内谷胱甘肽实时成像的研究,2016/4-2019/4,4万元,结题,主持

5. 福建省科技创新联合资金项目,2016Y9060,功能纳米材料在肿瘤细胞靶向治疗及细胞凋亡成像中的应用研究,2016/9-2019/9,10万元,结题,主持

6. 福建省卫生计生科研人才培养项目-中青年骨干人才培养项目, 2018-ZQN-75,肿瘤微环境响应纳米药物用于增强光动力治疗的研究,2018/5-2021/4,10万,结题,主持


已发表论文:(*为通讯作者,#为共同一作)

(1) Lei Ding#, Xiaolong Zhang#, Peiwen Yu, Fang Peng, Yupeng Sun,Yanni Wu, Zijin Luo, Hongsheng Li, Yongyi Zeng, Ming Wu*, Xiaolong Liu*, Genetically engineered nanovesicles mobilize synergistic antitumor immunity by ADAR1 silence and PDL1 blockade, Molecular Therapy, 2023, 10.1016/j.ymthe.2023.04.011.

(2) Yanni Wu#, Lei Ding#, Cheng Zheng, Hongsheng Li, Ming Wu, Yupeng Sun, Xiaolong Liu, Xiaolong Zhang*, Yongyi Zeng*, Targeted co-delivery of a photosensitizer and an antisense oligonucleotide based on an activatable hyaluronic acid nanosystem with endogenous oxygen generation for enhanced photodynamic therapy of hypoxic tumors. Acta Biomaterialia, 2022,153, 419-430.

(3) Xiaolong Zhang, Cheng Zheng, Lei Ding, Yanni Wu, Haipo Xu, Yupeng Sun, Yongyi Zeng, Xiaolong Liu*, Jingfeng Liu*, CRISPR-Cas12a coupled with terminal deoxynucleotidyl transferase mediated isothermal amplification for sensitive detection of polynucleotide kinase activity, Sensors & Actuators: B. Chemical, 2021, 330, 129317.

(4) Xiaolong Zhang, Ming Wu, Jiong Li, Shanyou Lan, Yongyi Zeng, Xiaolong Liu,* Jingfeng Liu*, Light-enhanced hypoxia-response of conjugated polymer nanocarrier for successive synergistic photodynamic and chemo-therapy, ACS Appl. Mater. Interfaces, 2018, 10 (26), 21909–21919.

(5) Lei Ding#, Xiao Lin#, Ziguo Lin, Yanni Wu, Xiaolong Liu, Jingfeng Liu, Ming Wu, Xiaolong Zhang*, Yongyi Zeng*, Cancer cell-targeted photosensitizer and therapeutic protein co-delivery nanoplatform based on a metal-organic framework for enhanced synergistic photodynamic and protein therapy. ACS Applied Materials & Interfaces, 2020, 12(33): 36906-36916.

(6) Lei Ding#, Yanni Wu#, Ming Wu, Qingfu Zhao, Hongsheng Li, Jingfeng Liu, Xiaolong Liu, Xiaolong Zhang*, Yongyi Zeng*, Engineered red blood cell biomimetic nanovesicle with oxygen self-supply for near-infrared-II fluorescence-guided synergetic chemo-photodynamic therapy against hypoxic tumors. ACS Applied Materials & Interfaces, 2021, 13(44): 52435-52449.

(7) Xiaolong Zhang, Xionghong Tan, Da Zhang, Naishun Liao, Youshi Zheng, Aixian Zheng, Yongyi Zeng, Xiaolong Liu *, Jingfeng Liu*, A cancer cell specific targeting nanocomplex for combination of mRNA-responsive photodynamic and chemo-therapy. Chemical Communications, 2017,53, 9979-9982.

(8) Xiaolong Zhang, Naishun Liao, Geng Chen, Aixian Zheng, Yongyi Zeng, Xiaolong Liu*, Jingfeng Liu*, A fluorescent turn on nanoprobe for simultaneous visualization of dual-targets involved in cell apoptosis and drug screening in living cells. Nanoscale, 2017, 9(30): 10861-10868.  

(9) Xiaolong Zhang#, Yongyi Zeng#, Aixian Zheng, Zhixiong Cai, Aimin Huang, Jinhua Zeng, Xiaolong Liu*, Jingfeng Liu*, A fluorescence based immunoassay for galectin-4 using gold nanoclusters and a composite consisting of glucose oxidase and a metal-organic framework, Microchim Acta, 2017, 184,1933–1940.

(10) Jing Wang#, Cheng Zheng#, Xionghong Tan, Aixian Zheng, Yongyi Zeng, Zhenxi Zhang, Xiaolong Zhang,* Xiaolong Liu,* Sensitive fluorometric determination of glutathione using fluorescent polymer dots and the dopamine-melanin nanosystem, Microchimica Acta, 2019, 186(8):568.

(11) Cheng Zheng, Lei Ding, Yanni Wu, Xionghong Tan, Yongyi Zeng, Xiaolong Zhang*, Xiaolong Liu, Jingfeng Liu*, A near-infrared turn-on fluorescence probe for glutathione detection based on nanocomposites of semiconducting polymer dots and MnO2 nanosheets, Analytical and Bioanalytical Chemistry, 2020, 412(29): 8167-8176.

授权发明专利:

(1) 张晓龙,刘景丰,刘小龙,曾永毅,吴名,一种乏氧响应聚合物纳米粒及其应用, 中国,ZL201810532353.4。

(2) 张晓龙,曾永毅,刘小龙,丁磊,一种同时包载光敏剂和蛋白质的肿瘤靶向纳米药物及其应用,中国,ZL202010653123.0。

(3) 杨黄浩,宋良,田中群,张晓龙,一种利用拉曼增强光谱检测食品中合成色素的方法,中国,CN201310295760.5。

(4) 刘景丰,刘小龙,张晓龙,廖乃顺,郑爱仙,曾永毅,一种细胞凋亡双色检测和成像探针及其应用,中国,CN201710432782.X。

(5) 杨黄浩,张晓龙,,b,梁虹,一种金纳米星及其制备方法和应用,中国,CN201510114250.2。

(6) 刘景丰,曾永毅,刘小龙,张晓龙,郑爱仙,廖乃顺,一种检测galectin?4的荧光酶联免疫分析方法,中国,CN 201610539941.1。


获奖情况

(1) 肝癌微创与诊疗一体化技术的研究及应用,福建省科学技术厅,科技进步一等奖,2022(刘景丰、刘小龙、曾永毅、张达、王培园、李阳、吴名、张翔、赵必星、张晓龙

(2) 光增强乏氧响应共轭聚合物纳米载体用于级联协同光动力和化学治疗, 福州市科学技术协会、中共福州市委组织部、福州市人力资源和社会保障局,2020,福州市自然科学优秀学术论文二等奖

其他

研究生招生专业:生物医学工程(学硕);生物工程(学硕);生物技术与工程(生物与医药专硕)。欢迎有志青年报考课题组研究生!

课题组网站:https://www.x-mol.com/groups/Liu_Xiaolong



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