争霸8官方入口

争霸8官方入口:争霸8官方入口

College of Biological Science and Engineering

郑爱仙*

发布日期:2013-06-27 发布者:

姓名:郑爱仙

性别:

职务:副研究员/硕士生导师

学历:博士

电子邮件:zax040500273@126.com

主要研究方向:生物标志物分析与成像、肿瘤免疫治疗

教育工作经历:

1. 2005/9-2009/6,争霸8官方入口,化学基地班,学士

2. 2005/9-2009/6,争霸8官方入口,分析化学专业,硕博连读

3. 2014/7-至今,福建医科大学孟超肝胆医院,助理研究员,副研究员

4. 2019/1-至今,争霸8官方入口孟超医学与交叉科学中心,副研究员

教学简介:


科研简介:主要从事生物标志物检测新技术开发以及肿瘤成像与治疗研究。主持国家自然科学基金青年项目、中国博士后科学基金面上项目、福建省自然科学基金面上项目、福建省卫生健康中青年骨干人才培养项目等多项国家级和省市级研究课题,以第一作者或通讯作者在Materials Today Bio、Molecular Therapy-Nucleic Acids、Biomaterials Science、Analytica Chimica Acta国际刊物上发表SCI论文十几篇,2021年入选福建省高层次人才(C类)。

社会兼职:中国生物医学工程学会会员

科研项目:

1. 基于二氧化锰调控的新生抗原疫苗用于肝癌精准免疫治疗的研究,福州市卫生健康科技计划项目(科研创新团队培育项目),2022-S-wt3,2023/01-2025/12,在研;

2. 细胞膜功能化的仿生纳米复合物用于增强肿瘤免疫治疗的研究,福建省科技创新联合资金项目,2020Y9046,2021/08-2024/08,在研,主持;

3. 基于免疫检查点的多功能核酸分子用于肿瘤免疫治疗的研究,福建省自然科学基金面上项目,2020J011157,2020/11-2023/11,在研,主持;

4. 基于响应型荧光探针的肿瘤微环境荧光成像方法研究,福建省卫生健康中青年骨干人才培养项目,2019-ZQN-88,2019/09-2022/08,在研,主持;

5. 新型近红外荧光探针用于肿瘤微环境特异响应的成像研究,中国博士后科学基金面上,2018M642557,2018/09-2021/08,在研,主持;

6. 核酸功能化聚多巴胺纳米探针在miRNA响应的肿瘤成像与治疗中的应用研究,国家自然科学基金,21705022,2018/01-2020/12,在研,主持;

7. 核酸功能化纳米探针在高灵敏成像分析中的应用研究,福建省科技创新联合资金项目,2017Y9115,2017/12-2020/12,在研,主持;

8. 肿瘤相关microRNA响应的肝癌成像与治疗一体化研究,福建省自然科学基金项目,2016J05207,2016/04-2019/04,在研,主持;

9. 基于多功能纳米材料的肝癌相关蛋白检测新方法研究,福建省卫生计生委青年科研课题,2015-1-95,2015/01-2018/12,在研,主持。


已发表论文:(*为通讯作者)

(1) Yiru Wang#, Ming Wu#, Xiaorong Wang#, Peiyuan Wang, Zhaoyu Ning, Yongyi Zeng, Xiaolong Liu, Haiyan Sun*, Aixian Zheng*. Biodegradable MnO2-based gene-engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunity. Materials Today Bio, 2023, 18: 100531.

(2) Aixian Zheng#, Yanlin Du#, Yiru Wang#, Youshi Zheng, Zhaoyu Ning, Ming Wu, Cuilin Zhang, Da Zhang, Jingfeng Liu* and Xiaolong Liu*. CD16/PD-L1 bi-specific aptamer for cancer immunotherapy through recruiting NK cells and acting as immunocheckpoint blockade. Molecular Therapy-Nucleic Acids, 2022, 27, 998-1009.

(3) Yanlin Du, Da Zhang, Yiru Wang, Ming Wu, Cuilin Zhang, Youshi Zheng, Aixian Zheng* and Xiaolong Liu *. A highly stable multifunctional aptamer for enhancing antitumor immunity against hepatocellular carcinoma by blocking dual immune checkpoints. Biomaterials Science, 2021, 9, 4159-4168.

(4) Aixian Zheng#, Haiyan Sun#, Yanlin Du, Yiru Wang, Ming Wu, Xiaolong Liu, Yongyi Zeng*, Jingfeng Liu*. A novel long-wavelength off-on fluorescence probe for nitroreductase analysis and hypoxia imaging, Analytica Chimica Acta, 2021, 1144, 76-84.

(5) Yanlin Du, Hui Liu, Jiaming Liang, Dongye Zheng, Jiong Li, Shubing Lan, Ming Wu, Aixian Zheng*, Xiaolong Liu*. Protein-assisted formation of gold clusters-MnO2 nanocomposite for fluorescence imaging of intracellular glutathione. Talanta, 2020, 209, 120524.

(6) Jing Wang, Hui Liu, Ming Wu, Xiaolong Liu, Haiyan Sun*, Aixian Zheng*. Water-soluble organic probe for pH sensing and imaging. Talanta, 2019, 205, 120095.

(7) Lei Fu#, Yanlin Du#, Zhenxi Zhang, Haiyan Sun, Aixian Zheng*, Xiaolong Liu*. Dual sensing of glutathione and acidic pH values by using MnO2 nanosheets and 3-acetyl-7-hydroxy-2H-chromen-2-one as a fluorescent pH probe, Microchimica Acta, 2019, 186, 491.

(8) Aixian Zheng, Xiaolong Zhang, Ju Gao, Xiaolong Liu*, Jingfeng Liu*, Peroxidase-like catalytic activity of copper ions and its application for highly sensitive detection of glypican-3. Analytica Chimica Acta, 2016, 941, 87-93.

(9) Yongyi Zeng#, Aixian Zheng#, Jing Wu, Zhixiong Cai, Aimin Huang*, Xiaolong Liu*, Horseradish peroxidase and aptamer dual-functionalized nanoprobe for the amplification detection of alpha-methylacyl-CoA racemase. Analytica Chimica Acta, 2015, 899, 100-105.

(10) Ai-Xian Zheng, Zhong-Xiao Cong, Jin-Ru Wang, Juan Li, Huang-Hao Yang*, Guo-Nan Chen, Highly-efficient peroxidase-like catalytic activity of grapheme dots for biosensing. Biosensors and Bioelectronics, 2013, 49, 519-524.

(11) Ai-Xian Zheng, Jin-Ru Wang, Juan Li, Xiao-Rong Song, Guo-Nan Chen, Huang-Hao Yang*, Enzyme-free fluorescence aptasensor for amplification detection of human thrombin via target-catalyzed hairpin assembly. Biosensors and Bioelectronics, 2012, 36, 217-221.

(12) Ai-Xian Zheng, Juan Li, Jin-Ru Wang, Xiao-Rong Song, Guo-Nan Chen, Huang-Hao Yang*, Enzyme-free signal amplification in the DNAzyme sensor via target- catalyzed hairpin assembly. Chemical Communications, 2012, 48, 3112-3114.

(13) Ai-Xian Zheng, Jin-Ru Wang, Juan Li, Xiao-Rong Song, Guo-Nan Chen, Huang-Hao Yang*, Nicking enzyme based homogeneous aptasensors for amplification detection of protein. Chemical Communications, 2012, 48, 374-376.


授权发明专利:

(1) 发明人:郑爱仙,刘小龙,刘景丰,孙海燕,一种硝基还原酶响应的乏氧探针化合物及其制备与应用,专利号:ZL 2019 1 1206912.3,授权号:CN 111303102 B,授权日期:2022.10.25,专利权人:福建医科大学孟超肝胆医院

(2) 发明人:刘小龙,刘景丰,郑爱仙,曾永毅,一种可响应pH的水溶性检测探针及其制备与应用,专利号:ZL 2019 1 0360230.1,授权号:CN 109988136 B,授权日期:2022.04.29,专利权人:福建医科大学孟超肝胆医院

(3) 发明人:刘景丰,刘小龙,郑爱仙,曾永毅,一种用于检测AMACR的双功能纳米探针、试剂盒及方法,专利号:ZL 2015 1 0240980.7,授权日期:2017.12.1,专利权人:福建医科大学孟超肝胆医院


获奖情况

刘景丰,刘小龙,王红阳,曾永毅,陈磊,黄爱民,曾金华,蔡志雄,郑爱仙,邢晓华,肝细胞癌早期诊断和预后判断的分子标志物筛选及临床应用,福建省科学技术进步奖,一等奖,2019



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